Research Projects 

The ASTS Foundation contributing $300,000 per year over seven years to help fund the Adult to Adult Living Donor Liver Transplant Cohort Study (A2ALL) at 10 U.S. Centers in conjunction with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Health Resource Services Administration (HRSA).

The A2ALL study will focus on the factors influencing clinical outcomes of living donor liver transplants for both donors and recipients as well as investigate important research issues such as liver regeneration, liver cancer, and infectious hepatitis.

"Transplant surgeons place a great deal of importance on the well-being of both donors and recipients. This partnership with NIDDK should give us solid data for the high quality patient care we all want to provide." James Schulak, M.D., ASTS Past President

About the Study

Over the last 20 years liver transplantation has become the standard of care and the only cure for end stage liver disease. Its success has led to over 4,500 transplants performed yearly. But there are at least 18,000 patients on the transplantation list awaiting cadaveric liver donation. As the waiting list has expanded, waiting time has also grown. As a result, patient mortality has increased while awaiting transplantation and patients are often critically ill by the time of transplantation. Among possible remedies, adult to adult living donor liver transplantation (AALDLT) has become widely accepted for pediatric transplantation. AALDLT is a more challenging procedure and has potentially greater risk to the donor because of the larger portion of liver that is required. Although still a small number relative to the several thousand adult cadaveric liver transplants performed annually, AALDLT has the potential for changing the face of liver transplantation. More about the study

Ancillary Studies Policy ¦ Prospective Study Subjects  ¦ Results

Meet the team

A team of surgeons, doctors and medical research professionals have been assembled to study Adult to Adult Living Donor Liver Transplantation. Click here to find biographical information about the Principal Investigators from the Data Coordinating Center, the nine different institutions participating in this study and the National Institutes of Health Project Officer.

For further information, please contact:

ASTS Executive Director
Katrina Crist, MBA
2461 S. Clark Street, Suite 640
Arlington, VA 22202

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Project Coordinator
Peg Hill-Callahan
A2ALL: The Adult to Adult Living Donor Liver Transplant Cohort Study
Data Coordinating Center
315 W. Huron Street, Suite 240
Ann Arbor, MI 48103-4262